LEVOFLOXACIN HEMIHYDRATE PDF

Each film-coated tablet of Levofloxacin mg Film-coated Tablets contains mg of levofloxacin equivalent to mg of levofloxacin hemihydrate. Name: Levofloxacin hemihydrate; Drug Entry: Levofloxacin. A synthetic fluoroquinolone (fluoroquinolones) antibacterial agent that inhibits the supercoiling. Find patient medical information for Levofloxacin Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings.

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Food has little effect on the absorption of levofloxacin. Expert Opin Drug Saf.

Musculoskeletal and connective tissue disorders. In a pharmacokinetic interaction study, levofloxacin did not affect the pharmacokinetics of theophylline which is a probe substrate for CYP1A2indicating that levofloxacin is not a CYP1A2 inhibitor.

Levofloxacin acts as a bactericide. In common with other fluoroquinolones, levofloxacin showed effects on cartilage blistering and cavities in rats and dogs. Heminydrate wide variety of other uncommon but serious adverse events have been associated with fluoroquinolone use, with varying degrees of evidence supporting causation.

Transient vision loss see section 4. Jaundice and severe liver injury, including cases with fatal acute liver failure, primarily in patients hemiyhdrate severe underlying diseases see section 4.

Levofloxacin Hemihydrate | CAS | SCBT – Santa Cruz Biotechnology

A review examining musculoskeletal complications of fluoroquinolones proposed guidelines with respect to administration to athletes, that called for avoiding all use of fluoroquinolone antibiotics if possible, and if they are used: CNS effects including confusional state, convulsion, hallucination, and tremor have been observed in post marketing experience. However a pronounced lowering of the cerebral seizure threshold may occur when quinolones are given concurrently with theophylline, non-steroidal anti-inflammatory drugs, or other agents which lower the seizure threshold.

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No special requirements Any unused medicinal product or waste material should be disposed of in accordance with local requirements. The tablets may be taken during meals or between meals.

Photosensitisation has been reported with levofloxacin see section 4. These effects can be attributed to inhibition of topoisomerase II.

Use in humans is based on in vitro Bacillus anthracis susceptibility data and on animal experimental data together with limited human data. Archived PDF from the original on 17 November Therapeutics and clinical risk management. Its spectrum of activity includes most strains of bacterial pathogens responsible for respiratory, urinary tract, gastrointestinal, levoflixacin abdominal infections, including Gram negative Escherichia coliHaemophilus influenzaeKlebsiella pneumoniaeLegionella pneumophilaMoraxella catarrhalisProteus mirabilisand Pseudomonas aeruginosaGram positive methicillin -sensitive but not methicillin-resistant Staphylococcus aureusStreptococcus pneumoniaeStaphylococcus epidermidisEnterococcus faecalisand Streptococcus pyogenesand atypical bacterial pathogens Chlamydophila pneumoniae and Mycoplasma pneumoniae.

Levoflooxacin from the original on 1 February The use of levofloxacin, especially if prolonged, may result in overgrowth of non-susceptible organisms. You won’t have to remember an extra levofloxcin and password. Therefore, if levofloxacin has to be used in these patients, potential occurrence of haemolysis should be monitored.

Levofloxacin mg Film-coated Tablets – Summary of Product Characteristics (SmPC) – (eMC)

Dysglycaemia As with all quinolones, disturbances in blood glucose, including both hypoglycaemia and hyperglycaemia have been reported, usually in diabetic patients receiving concomitant treatment with an oral hypoglycaemic agent e.

Create an account quickly and easily with your preferred social network account. Levofloxacin caused no impairment of fertility or reproductive performance in rats and its only effect on fetuses was lrvofloxacin maturation as a result of maternal toxicity. Archived PDF from the original on 14 April Patients predisposed to seizures Quinolones may lower the seizure threshold and may trigger seizures. Levofloxacin is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria.

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Archived from the original on 5 November The bioavailability of Levofloxacin mg Film-coated Tablets is significantly reduced when administered together with sucralfate.

Phlebitis Hypotension Respiratory, thoracic and mediastinal disorders Dyspnoea Bronchospasm Pneumonitis allergic Gastro- intestinal disorders Diarrhoea Vomiting Nausea Abdominal pain Dyspepsia Flatulence Constipation Diarrhoea — haemorrhagic which in very rare cases may be indicative of enterocolitis, including pseudomembranous colitis see section 4.

No adjustment of dose is required in the elderly, other than that imposed by consideration of renal function see section 4. These side effects can involve the tendons, muscles, joints, nerves, and central nervous system. Some undesirable effects e.

Archived PDF from the original on 11 June Blood and lymphatic system disorders. By signing up, you indicate that you have read and agree to the terms in our privacy policy. C Risk not ruled out. Archived from the original on 1 May Respiratory, thoracic and mediastinal disorders. These findings were more marked in young animals.

Levofloxacin Hemihydrate (CAS 138199-71-0)

For the full list of excipients, see section 6. For the above-mentioned infections Levofloxacin mg Film-coated Tablets should be used only when it is considered inappropriate to use antibacterial agents that are commonly recommended for the initial treatment of these infections.

It is not known if levofloxacin is released in mother’s milk, but other fluoroquinolones are.